Science-Based Guide

Alkaline water and acid reflux: what the research says.

An evidence-based look at what peer-reviewed science tells us about alkaline water's potential role in managing acid reflux symptoms — including the boundaries of what the research actually shows.

★ Medical disclaimer

This content is for educational purposes only and does not constitute medical advice. Always consult your healthcare provider before making changes to your diet or treatment plan.

01 · The Condition

Understanding acid reflux.

Acid reflux, clinically known as gastro-oesophageal reflux disease (GERD), occurs when stomach acid flows back into the oesophagus. This backwash can irritate the lining, causing the burning sensation commonly known as heartburn.

Common symptoms

Burning sensation in the chest (heartburn), regurgitation of food or sour liquid, difficulty swallowing, a sensation of a lump in the throat. Some people also experience chronic cough, hoarseness, or breathing changes.

Standard treatments

Conventional management typically includes lifestyle modifications (dietary changes, weight management, elevating the head of the bed during sleep), over-the-counter antacids and H2 receptor blockers, and prescription medications like proton pump inhibitors (PPIs). Always work with your doctor on a treatment plan.

The role of pepsin

A key factor in reflux-related tissue damage is an enzyme called pepsin. Pepsin is a digestive enzyme produced in the stomach that breaks down proteins. When stomach contents reflux into the oesophagus and throat, pepsin can adhere to the tissue and cause irritation. This is where pH becomes interesting.

02 · The Research

What the research says — peer-reviewed.

The most widely cited study on this topic was conducted by Dr Jamie A. Koufman and Dr Nikki Johnston, published in 2012 in the Annals of Otology, Rhinology & Laryngology — a peer-reviewed medical journal.

★ Peer-Reviewed · 2012

Koufman & Johnston (2012)

"Unlike conventional drinking water, pH 8.8 alkaline water instantly denatures pepsin, rendering it permanently inactive. In addition, it has good acid-buffering capacity."

The study examined the effect of alkaline water with a pH of 8.8 on pepsin activity in laboratory conditions. Researchers found that water at this pH level irreversibly denatured human pepsin — it became permanently inactive. They also found alkaline water demonstrated good acid-buffering capacity.

Important context

It's essential to understand the scope of these findings. This was an in vitro study — experiments conducted in a laboratory setting rather than inside the human body. The researchers demonstrated a mechanism by which alkaline water might benefit reflux sufferers, but additional clinical research is needed to confirm these findings translate to the same effect in real-world conditions.

03 · The Mechanism

How pH levels may matter.

Pepsin is most active at highly acidic pH levels (around pH 2). As pH increases (becomes less acidic), pepsin activity decreases. At mildly elevated pH levels, pepsin is merely inactivated temporarily. At pH 8.8 and above, the study showed pepsin is permanently denatured.

★ pH Scale Reference

pH 2Stomach acid — pepsin most active
pH 6.5–7.5Regular tap / bottled water
pH 8.8Study threshold — irreversible pepsin denaturation
pH 10Designer Water — above the study threshold
★ Acid-buffering capacity

Beyond pepsin denaturation, the study noted alkaline water demonstrated good acid-buffering capacity. This means it may help maintain a higher pH in the oesophageal environment for longer than regular water, which has minimal buffering capacity.

04 · The Limits

What alkaline water won't do.

Transparency matters. While the research is promising, it's important to be clear about the boundaries of what alkaline water can and cannot do.

It is not a cure for GERD

No water, regardless of pH, can cure a structural or chronic digestive condition.

It does not replace medication

If your doctor has prescribed PPIs, H2 blockers or other treatments, do not stop them on your own.

It is not a diagnostic tool

Reflux symptoms can mimic other conditions. Get properly diagnosed.

It won't change your blood pH

Your body maintains blood pH on its own. The mechanism here is local — in the oesophagus, not systemic.

★ The honest position

What the evidence suggests is that alkaline water may serve as a useful complement to conventional reflux management strategies — one factor among many in a holistic approach to digestive health that includes diet, lifestyle and medical care.

05 · Designer Water

Why people choose Designer Water.

Designer Water is a South African premium alkaline water with a stable pH of 10 — exceeding the pH 8.8 threshold examined in the Koufman & Johnston study. Produced in Midrand, Gauteng. Every bottle independently tested.

Designer Water contains added minerals including calcium, magnesium and potassium. Every batch is tested to ensure consistent pH and mineral content, so you know exactly what you're drinking with every bottle. Available in 330ml, 500ml, 750ml, 1L, 5L and 10L.

FAQ

Acid reflux + alkaline water — your questions.

Will alkaline water cure my acid reflux?
No. Alkaline water is not a cure for acid reflux or GERD. The research suggests it may serve as a useful complement to conventional management — but it does not replace medication or medical care.
Can I drink alkaline water with my reflux medication?
In most cases yes, but always check with your doctor or pharmacist first — especially if you take PPIs, H2 blockers or other prescribed treatments. Your prescribing physician knows your individual situation.
What pH is needed to denature pepsin?
The Koufman & Johnston study found that water at pH 8.8 irreversibly denatured human pepsin in laboratory conditions. Designer Water at pH 10 exceeds this threshold.
How quickly might I notice a difference?
Individual responses vary. Some customers report changes within days. Some don't notice an effect. Alkaline water is one factor in a broader reflux management approach — not a quick fix.
Is the research conclusive?
No. The Koufman & Johnston study is the most cited paper on this topic, but it was a laboratory study (in vitro). Larger clinical trials in real-world conditions are still needed to confirm the findings translate fully to humans.
Can I use alkaline water as my only water?
Yes. Alkaline water at pH 8-10 is safe to drink as your primary water source for healthy adults. If you have kidney disease or specific medical conditions, consult your doctor.
★ Important Disclaimer

This content is for educational purposes only and does not constitute medical advice, diagnosis or treatment. The research cited describes laboratory findings that have not been confirmed through large-scale clinical trials in humans. Individual results may vary. Always consult a qualified healthcare professional for personalised guidance.

★ pH 10 — Above the study threshold

Try the water at pH 10.

Designer Water pH10 — alkaline at pH 10+, mineralised, hydrogen-infused. Bottled in Midrand under SANBWA, ISO 22000 and four other independent certifications.